ACUTE CORONARY SYNDROME AND OBESITY PARADOX
DOI:
https://doi.org/10.5281.inno202513Keywords:
Acute coronary syndrome, modifiable risk factors, obesity paradox, body mass indexAbstract
Acute coronary syndrome (ACS) is one of the most common cardiovascular diseases worldwide.Acute coronary syndrome can have many causes, but the pathophysiologies are generally similar. Laboratory findings such as cardiac troponins and myoglobin are important when monitoring ACS in the clinic. Modifiable risk factors and lifestyle that can lead to acute coronary syndrome and change the course of the disease are important. Dietary fatty acid pattern, smoking, alcohol use and physical activity are among the most important modifiable risk factors. It is stated that dietary fatty acid content, moderate physical activity may be protective and therapeutic against ACS. Another important issue is the relationship between obesity and ACS. Many studies with large samples have shown that obesity causes a U-shaped death in acute coronary syndrome. Moderate obesity has been shown to reduce the risk of death in ACS.
References
Andsoy II, Sevinc Tastan R, Emine Iyigun R, Kopp LR. (2015). Knowledge and attitudes towards cardiovascular disease in a population of North Western Turkey: a cross-sectional survey. International Journal of Caring Sciences, 8(1):115.
Bucholz EM, Rathore SS, Reid KJ, Jones PG, Chan PS, Rich MW, et al. (2012). Body mass index and mortality in acute myocardial infarction patients. The American Journal of Medicine, 125(8):796–803.
Buscemi S, Nicolucci A, Lucisano G, Galvano F, Grosso G, Belmonte S, et al. (2014). Habitual fish intake and clinically silent carotid atherosclerosis. Nutrition Journal, 13(1):1–8.
Cannon CP, Brindis RG, Chaitman BR, Cohen DJ, Cross Jr JT, Drozda Jr JP, et al. (2013). 2013 ACCF/AHA key data elements and definitions… Circulation, 127(9):1052–89.
Chang H-J, Lin FY, Lee S-E, Andreini D, Bax J, Cademartiri F, et al. (2018). Coronary atherosclerotic precursors… Journal of the American College of Cardiology, 71(22):2511–22.
Costanzo P, Cleland JG, Pellicori P, Clark AL, Hepburn D, Kilpatrick ES, et al. (2015). The obesity paradox in type 2 diabetes mellitus… Annals of Internal Medicine, 162(9):610–8.
Crea F, Liuzzo G. (2013). Pathogenesis of acute coronary syndromes. Journal of the American College of Cardiology, 61(1):1–11.
Dekker MS, Mosterd A, van’t Hof AW, Hoes AW. (2010). Novel biochemical markers in suspected ACS… Heart, 96(13):1001–10.
Edmondson D, Richardson S, Falzon L, Davidson KW, Mills MA, Neria Y. (2012). PTSD prevalence and risk of recurrence… PLoS ONE, 7(6):e38915.
Goel S, Sharma A, Garg A. (2018). Effect of alcohol consumption on cardiovascular health. Current Cardiology Reports, 20(4):1–10.
Haque R, Hafiz FB, Habib M, Radeen KR, Islam LN. (2022). Role of complete blood count, antioxidants… African Journal of Biological Sciences, 4(1):37–47.
Huffman JC, DuBois CM, Mastromauro CA, Moore SV, Suarez L, Park ER. (2016). Positive psychological states… Journal of Health Psychology, 21(6):1026–36.
Libby P. (2021). The changing landscape of atherosclerosis. Nature, 592(7855):524–33.
Lip GY, Huber K, Andreotti F, Arnesen H, Airaksinen JK, Cuisset T, et al. (2010). Antithrombotic management… European Heart Journal, 31(11):1311–8.
Makki N, Brennan TM, Girotra S. (2015). Acute coronary syndrome. Journal of Intensive Care Medicine, 30(4):186–200.
Mathews MJ, Liebenberg L, Mathews EH. (2015). The mechanism by which moderate alcohol consumption influences coronary heart disease. Nutrition Journal, 14(1):1–12.
Moe KT, Wong P. (2010). Current trends in diagnostic biomarkers… Ann Acad Med Singapore, 39(3):210–5.
Monzani D, D’Addario M, Fattirolli F, Giannattasio C, Greco A, Quarenghi F, et al. (2018). Clustering of lifestyle risk factors… Applied Psychology: Health and Well-Being, 10(3):434–56.
Niedziela J, Hudzik B, Niedziela N, Gąsior M, Gierlotka M, Wasilewski J, et al. (2014). The obesity paradox in acute coronary syndrome… European Journal of Epidemiology, 29(11):801–12.
Nikus K, Pahlm O, Wagner G, Birnbaum Y, Cinca J, Clemmensen P, et al. (2010). Electrocardiographic classification… Journal of Electrocardiology, 43(2):91–103.
Notara V, Panagiotakos DB, Kouroupi S, Stergiouli I, Kogias Y, Stravopodis P, et al. (2015). Smoking determines the 10-year prognosis… Tobacco Induced Diseases, 13(1):1–9.
Oreopoulos A, Padwal R, Kalantar-Zadeh K, Fonarow GC, Norris CM, McAlister FA. (2008). Body mass index and mortality in heart failure… American Heart Journal, 156(1):13–22.
Otsuka F, Joner M, Prati F, Virmani R, Narula J. (2014). Clinical classification of plaque morphology… Nature Reviews Cardiology, 11(7):379–89.
Pirhonen L, Olofsson EH, Fors A, Ekman I, Bolin K. (2017). Effects of person‐centred care. Health Policy, 121(2):169–79.
Ramasamy I. (2011). Biochemical markers in acute coronary syndrome. Clinica Chimica Acta, 412(15–16):1279–96.
Romagnoli E, Biondi-Zoccai G, Sciahbasi A, Politi L, Rigattieri S, Pendenza G, et al. (2012). Radial versus femoral… Journal of the American College of Cardiology, 60(24):2481–9.
Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, et al. (2006). Association of bodyweight with mortality… The Lancet, 368(9536):666–78.
Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. (2016). Epidemiology of coronary heart disease… Annals of Translational Medicine, 4(13).
Scirica BM. (2010). Acute coronary syndrome: emerging tools… Journal of the American College of Cardiology, 55(14):1403–15.
Snaterse M, Scholte Op Reimer W, Dobber J, Minneboo M, Ter Riet G, Jorstad H, et al. (2015). Smoking cessation after ACS… Netherlands Heart Journal, 23(12):600–7.
Stein E, Barbiero S, Lucia Portal V, Luz Vd, Marcadenti A. (2021). Association between deep subcutaneous adipose tissue… International Journal of Cardiovascular Sciences, 35:39–45.
Ter Hoeve N, Huisstede BM, Stam HJ, van Domburg RT, Sunamura M, van den Berg-Emons RJ. (2015). Does cardiac rehabilitation… Physical Therapy, 95(2):167–79.
Timmis A. (2015). Acute coronary syndromes. BMJ, 351.
Toma A, Paré G, Leong DP. (2017). Alcohol and cardiovascular disease… Current Atherosclerosis Reports, 19(3):1–7.
Uretsky S, Messerli FH, Bangalore S, Champion A, Cooper-DeHoff RM, Zhou Q, et al. (2007). Obesity paradox in hypertension and CAD… The American Journal of Medicine, 120(10):863–70.
Varela A, Davos CH, Doehner W. (2020). Diet and nutritional aspects of cardiac rehabilitation. ESC Handbook of Cardiovascular Rehabilitation.
Wu AH, Christenson RH, Greene DN, Jaffe AS, Kavsak PA, Ordonez-Llanos J, et al. (2018). Clinical laboratory practice recommendations… Clinical Chemistry, 64(4):645–55.
Yadav P, Joseph D, Joshi P, Sakhi P, Jha R, Gupta J. (2010). Clinical profile & risk factors… National J Comm Med, 1(2):150–1.
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